Scientific
Praxis
Vector
Scientific
Praxis
Vector
ANTHROPOCENE
ANTHROPOCENE
NOVACENE
NOVACENE
NOVACENE
Unbounded Self-Organizing
-Quantum Agentic Selves
Unobservables Experienced
Bounded Automated Mechanisms
Observables Engineered Artifacts
Observables Engineered Artifacts
Self-Organizing
Sentient Agentic
Self-Organizing
Sentient Agentic
Self-Organizing
Sentient Agentic
Active
Inference
Agent
Active
Inference
Agent
Active
Inference
Agent
Biofirm
Biofirm
Biofirm
Xenobots
Xenobots
Xenobots
Self-Writing
Internet Computer
Protocol
Self-Writing
Internet Computer
Protocol
Self-Writing
Internet Computer
Protocol
Conscious
Agent Theory
Conscious
Agent Theory
Conscious
Agent Theory
Seity
Seity
Seity
Panpsychism
Panpsychism
Panpsychism
Orchestrated
Objective
Reduction
Orchestrated
Objective
Reduction
Orchestrated
Objective
Reduction
Integrated
Information
Theory
Integrated
Information
Theory
Integrated
Information
Theory
Ashby
Homeostat
Ashby
Homeostat
Ashby
Homeostat
Agentic
Economics
Agentic
Economics
Agentic
Economics
NDE
NDE
NDE
Unitarianism
Unitarianism
Unitarianism
Teillhardism
Teillhardism
Teillhardism
Taoism
Taoism
Taoism
Vendata
Vendata
Vendata
Shintoism
Shintoism
Shintoism
Neo-Liberalism
Neo-Liberalism
Neo-Liberalism
Humanism
Humanism
Humanism
Animism
Animism
Animism
Psychedelics
Psychedelics
Psychedelics
Sufism
Sufism
Sufism
Buddhism
Buddhism
Buddhism
Catholicism
Catholicism
Catholicism
Christian
Evangelicals
Christian
Evangelicals
Christian
Evangelicals
Orthodox
Judaism
Orthodox
Judaism
Orthodox
Judaism
Pentecostal
Pentecostal
Pentecostal
Mormonism
Mormonism
Mormonism
Wahabism
Wahabism
Wahabism
Communism
Communism
Communism
Marxism
Marxism
Marxism
Secular Rationalism
Secular Rationalism
Secular Rationalism
Socialism
Socialism
Socialism
Libertarianism
Libertarianism
Libertarianism
Free Market
Capitalism
Free Market
Capitalism
Free Market
Capitalism
Atheism
Atheism
Atheism
New Apostolic
Reformation
New Apostolic
Reformation
New Apostolic
Reformation
Effective
Altruism
Effective
Altruism
Effective
Altruism
AltRight
AltRight
AltRight
Ethereum
Ethereum
Ethereum
Bitcoin
Bitcoin
Bitcoin
CruiseAi
CruiseAi
CruiseAi
Claude 3.5
Claude 3.5
Claude 3.5
Agentic Mesh
Agentic Mesh
Agentic Mesh
Meta Llama 3
Meta Llama 3
Meta Llama 3
Gemini
Gemini
Gemini
Perplexity
Perplexity
Perplexity
GPT4o
GPT4o
GPT4o
SandboxAQ
SandboxAQ
SandboxAQ
SciAgents
SciAgents
SciAgents
DeepSeek R3
DeepSeek R3
DeepSeek R3
AlphaFold
AlphaFold
AlphaFold
Reasoning
Chains
Reasoning
Chains
Reasoning
Chains
The Anthropocene to Novacene Transition:
Matter to Minds & Minds to Mattering
The Anthropocene to Novacene Transition:
Matter to Minds & Minds to Mattering
(* In bold last 5 years)
(* In bold last 5 years)
(* In bold last 5 years)
FP1 Introduction With
Dr. John H. Clippinger
FP1 Introduction With Dr. John H. Clippinger
FP1 Introduction With
Dr. John H. Clippinger
FP1 Introduction With Dr. John H. Clippinger
First Principles First is a platform dedicated to exploring sentient technologies and their societal impact. We bring together diverse experts to provide scientifically-grounded information on natural and synthetic intelligences, focusing on innovative thinkers who challenge conventional wisdom. As we enter the "age of sentience," we track the development of self-aware, multiscale agents and explore the shift from traditional enlightenment thinking to a new paradigm of "entanglement." Through curated content and expert analysis, we aim to advance our understanding of these technologies and their potential to reshape society.
Trusted by the world’s most innovative teams
Horizon Search
Horizon Search
Horizon Search
Horizon Search
Horizon Search
In this episode, I sit down with Will Ratcliff, a full professor at Georgia Tech and director of the interdisciplinary graduate program in Quantitative Biosciences, to explore the evolutionary secrets of cooperation, complexity, and stability. Will’s research focuses on how multicellular life evolved and what biology can teach us about building stable, adaptive systems—whether in AI, governance, or economics.
In this episode, Dr. Mihaela Ulieru is joined by John-Henry Clippinger, a leading researcher, entrepreneur, and author specializing in decentralized governance, blockchain ecosystems, and artificial intelligence. With a background in cognitive science and complex adaptive systems, he has contributed extensively to the development of trust-based digital identity, tokenomics, and self-sovereign governance models.
Michael Levin dives deep into the intersection of biology and artificial intelligence, exploring how individual units—whether cells or humans—can form cohesive, goal-driven systems. Sharing insights into "cognitive glue," the mechanisms that bind entities into intelligent collectives, and how these principles apply to designing ethical AI. We also tackle the challenge of misinformation, the fluidity of memory and understanding, and the potential dangers and promises of AI-driven societal structures.
In this episode, I sit down with Will Ratcliff, a full professor at Georgia Tech and director of the interdisciplinary graduate program in Quantitative Biosciences, to explore the evolutionary secrets of cooperation, complexity, and stability. Will’s research focuses on how multicellular life evolved and what biology can teach us about building stable, adaptive systems—whether in AI, governance, or economics.
In this episode, Dr. Mihaela Ulieru is joined by John-Henry Clippinger, a leading researcher, entrepreneur, and author specializing in decentralized governance, blockchain ecosystems, and artificial intelligence. With a background in cognitive science and complex adaptive systems, he has contributed extensively to the development of trust-based digital identity, tokenomics, and self-sovereign governance models.
Michael Levin dives deep into the intersection of biology and artificial intelligence, exploring how individual units—whether cells or humans—can form cohesive, goal-driven systems. Sharing insights into "cognitive glue," the mechanisms that bind entities into intelligent collectives, and how these principles apply to designing ethical AI. We also tackle the challenge of misinformation, the fluidity of memory and understanding, and the potential dangers and promises of AI-driven societal structures.
Renowned neuroscientist Stuart Hameroff explores the groundbreaking concept of quantum consciousness, proposing that microtubules, quantum coherence, and aromatic rings play a key role in consciousness. Combining physics, biology, and neuroscience, he challenges traditional brain theories and examines implications for AI, spirituality, and quantum computing.
The Prospect of Quantum Conscious Autonomous Agents
How might advances in Quantum Complexity inform the next generation of AI agents?
Autonomous DeSci Agents & Free Energy Principle
How might Decentralized Scientific Agents and the Free Energy Principle offer scale and domain free risk adjusted credentials for climate finance, economic value recognition and allocation and adjudication and enforcement of rights?
Autonomous DeSci Agents & Free Energy Principle
How might Decentralized Scientific Agents and the Free Energy Principle offer scale and domain free risk adjusted credentials for climate finance, economic value recognition and allocation and adjudication and enforcement of rights?
Autonomous DeSci Agents & Free Energy Principle
How might Decentralized Scientific Agents and the Free Energy Principle offer scale and domain free risk adjusted credentials for climate finance, economic value recognition and allocation and adjudication and enforcement of rights?
Autonomous DeSci Agents & Free Energy Principle
How might Decentralized Scientific Agents and the Free Energy Principle offer scale and domain free risk adjusted credentials for climate finance, economic value recognition and allocation and adjudication and enforcement of rights?
Persistent Self-Governing Entities
How might living, self-aware agents inform DAOs and decentralized Governance?
Persistent Self-Governing Entities
How might living, self-aware agents inform DAOs and decentralized Governance?
Persistent Self-Governing Entities
How might living, self-aware agents inform DAOs and decentralized Governance?
Persistent Self-Governing Entities
How might living, self-aware agents inform DAOs and decentralized Governance?
Interface of Classical and Quantum Consciousness
Is it really necessary to include an interface between quantum and classical states to account for natural and synthetic intelligences?
Interface of Classical and Quantum Consciousness
Is it really necessary to include an interface between quantum and classical states to account for natural and synthetic intelligences?
Interface of Classical and Quantum Consciousness
Is it really necessary to include an interface between quantum and classical states to account for natural and synthetic intelligences?
Interface of Classical and Quantum Consciousness
Is it really necessary to include an interface between quantum and classical states to account for natural and synthetic intelligences?
New Era of Computational Consciousness
Are there “first principles” for a science of living cognizant beings – synthetic and natural? Are we in the midst of a paradigm shift (in the Thomas Kuhnian sense) in what is considered mental and material reality and the reimagination of societal and economic institutions as nested living cognitive beings? Are we entering a new sphere of existence co-inhabited by other intentional biological and synthetic beings? What is the evidence?
Are there “first principles” for a science of living cognizant beings – synthetic and natural? Are we in the midst of a paradigm shift (in the Thomas Kuhnian sense) in what is considered mental and material reality and the reimagination of societal and economic institutions as nested living cognitive beings? Are we entering a new sphere of existence co-inhabited by other intentional biological and synthetic beings? What is the evidence?
The goal is to have different episodes build upon one another to identify a working consensus for a new scientific paradigm and computational framework for natural and synthetic agents. The audience will be engaged in this process through questions and comments with the guests and through their interactions with synthetic AI models of different schools of thought.
The goal is to have different episodes build upon one another to identify a working consensus for a new scientific paradigm and computational framework for natural and synthetic agents. The audience will be engaged in this process through questions and comments with the guests and through their interactions with synthetic AI models of different schools of thought.
Synthetic Cognizant Agents
Paradigm Shifts
Computational Frameworks for Scalable Applications
Mind Fields of Nested Agents
"We’re bridging the gap between neuroscience, physics, biology, and artificial intelligence, creating sentient systems that can think, adapt, and act like humans"
Dr. John H. Clippinger
Co-Founder
"We’re bridging the gap between neuroscience, physics, biology, and artificial intelligence, creating sentient systems that can think, adapt, and act like humans"
Dr. John H. Clippinger
Co-Founder
"We’re bridging the gap between neuroscience, physics, biology, and artificial intelligence, creating sentient systems that can think, adapt, and act like humans"
Dr. John H. Clippinger
Co-Founder
"We’re bridging the gap between neuroscience, physics, biology, and artificial intelligence, creating sentient systems that can think, adapt, and act like humans"
Dr. John H. Clippinger
Co-Founder
Inventions Come and Go Discoveries Are Forever
Science discovers those first principles that forever change our realities and ourselves.
Science discovers those first principles that forever change our realities and ourselves.
01.
01.
Evidence-Based and Augmented Collective Deliberation and Belief Alignment
A goal here is to have a principled AI agent framework that can augment complex human and institutional deliberative processes and help achieve group alignments around shared beliefs grounded in evidence and transparent, self-explanatory and evolving models.
02.
02.
Edge-Based Distributed, Secure Data, Identity- and Privacy-Preserving
We focus on creating edge networks of secure, distributed models that operate locally, ensuring data privacy and identity sovereignty and to minimizing the need for extensive computational resources.
03.
03.
Embed DeSci Computational Method in Societal Processes
In order to restore truth and authority to societal, economic, business, and governmental processes, we explore means for embedding computational scientific methods to resolve uncertainty and to accelerate learning and risk mitigation.
04.
04.
Regenerative Finance and Valuing Bioregional Credits
A major impediment to financing carbon sequestration and biodiversity is the lack of scalable and trusted scientific metrics for verification. Active Inference and FEP models offer a scientifically grounded basis for valuing natural assets and generating nature -based currencies and assets. FP1.ai wants to to collaborate with those engaged in bioregional finance and geospatial model to undertake pilot projects.
"Here’s to the Crazy Ones"
“Here’s to the crazy ones. The misfits. The rebels. The troublemakers... Because the people who are crazy enough to think they can change the world, are the ones who do.”
We celebrate those who challenge the status quo and push the boundaries of what’s possible.
(* Inspired by Apple’s Think Different campaign)
Researcher, and entrepreneur in self-organizing agents, AI and computational linguistics, policy advocate for privacy, self-sovereign identity, and advocate for new generation of societal and ecological polities and institutions grounded in scientific first principles.
Seasoned entrepreneur and investor with an MBA from the University of British Columbia. Founder and CEO of Horizon Search; advisor specializing in scaling ventures using artificial intelligence and emerging technologies to build resilient organizations.
Studies consciousness, visual perception and evolutionary psychology through mathematical models and psychophysical experiments. Research focuses on how perception relates to objective reality and the fundamental nature of conscious experience across disciplines.
Specializes in applying classical and quantum information-theoretic principles to developmental biology and cognitive neuroscience. This interdisciplinary research explores how information processing shapes biological development and neural functions across scales.
Chairs the Department of Psychiatry and Co-Directs the Institute for the Neurosciences at Brigham and Women's Hospital. Serves as Stanley Cobb Professor of Psychiatry at Harvard Medical School, focusing on neuropsychiatric research and integration.
"Here’s to the Crazy Ones"
“Here’s to the crazy ones. The misfits. The rebels. The troublemakers... Because the people who are crazy enough to think they can change the world, are the ones who do.”
We celebrate those who challenge the status quo and push the boundaries of what’s possible.
(* Inspired by Apple’s Think Different campaign)
Researcher, and entrepreneur in self-organizing agents, AI and computational linguistics, policy advocate for privacy, self-sovereign identity, and advocate for new generation of societal and ecological polities and institutions grounded in scientific first principles.
Seasoned entrepreneur and investor with an MBA from the University of British Columbia. Founder and CEO of Horizon Search; advisor specializing in scaling ventures using artificial intelligence and emerging technologies to build resilient organizations.
Studies consciousness, visual perception and evolutionary psychology through mathematical models and psychophysical experiments. Research focuses on how perception relates to objective reality and the fundamental nature of conscious experience across disciplines.
Specializes in applying classical and quantum information-theoretic principles to developmental biology and cognitive neuroscience. This interdisciplinary research explores how information processing shapes biological development and neural functions across scales.
Chairs the Department of Psychiatry and Co-Directs the Institute for the Neurosciences at Brigham and Women's Hospital. Serves as Stanley Cobb Professor of Psychiatry at Harvard Medical School, focusing on neuropsychiatric research and integration.
"Here’s to the Crazy Ones"
“Here’s to the crazy ones. The misfits. The rebels. The troublemakers... Because the people who are crazy enough to think they can change the world, are the ones who do.”
We celebrate those who challenge the status quo and push the boundaries of what’s possible.
(* Inspired by Apple’s Think Different campaign)
Researcher, and entrepreneur in self-organizing agents, AI and computational linguistics, policy advocate for privacy, self-sovereign identity, and advocate for new generation of societal and ecological polities and institutions grounded in scientific first principles.
Seasoned entrepreneur and investor with an MBA from the University of British Columbia. Founder and CEO of Horizon Search; advisor specializing in scaling ventures using artificial intelligence and emerging technologies to build resilient organizations.
Studies consciousness, visual perception and evolutionary psychology through mathematical models and psychophysical experiments. Research focuses on how perception relates to objective reality and the fundamental nature of conscious experience across disciplines.
Specializes in applying classical and quantum information-theoretic principles to developmental biology and cognitive neuroscience. This interdisciplinary research explores how information processing shapes biological development and neural functions across scales.
Chairs the Department of Psychiatry and Co-Directs the Institute for the Neurosciences at Brigham and Women's Hospital. Serves as Stanley Cobb Professor of Psychiatry at Harvard Medical School, focusing on neuropsychiatric research and integration.
"Here’s to the Crazy Ones"
“Here’s to the crazy ones. The misfits. The rebels. The troublemakers... Because the people who are crazy enough to think they can change the world, are the ones who do.”
We celebrate those who challenge the status quo and push the boundaries of what’s possible.
(* Inspired by Apple’s Think Different campaign)
Researcher, and entrepreneur in self-organizing agents, AI and computational linguistics, policy advocate for privacy, self-sovereign identity, and advocate for new generation of societal and ecological polities and institutions grounded in scientific first principles.
Seasoned entrepreneur and investor with an MBA from the University of British Columbia. Founder and CEO of Horizon Search; advisor specializing in scaling ventures using artificial intelligence and emerging technologies to build resilient organizations.
Studies consciousness, visual perception and evolutionary psychology through mathematical models and psychophysical experiments. Research focuses on how perception relates to objective reality and the fundamental nature of conscious experience across disciplines.
Specializes in applying classical and quantum information-theoretic principles to developmental biology and cognitive neuroscience. This interdisciplinary research explores how information processing shapes biological development and neural functions across scales.
Chairs the Department of Psychiatry and Co-Directs the Institute for the Neurosciences at Brigham and Women's Hospital. Serves as Stanley Cobb Professor of Psychiatry at Harvard Medical School, focusing on neuropsychiatric research and integration.
